Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.
Originalsprog | Engelsk |
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Artikelnummer | 16093 |
Tidsskrift | Nature Microbiology |
Vol/bind | 1 |
Udgave nummer | 9 |
Antal sider | 9 |
ISSN | 2058-5276 |
DOI | |
Status | Udgivet - 2016 |
Bibliografisk note
CURIS 2016 NEXS 252
ID: 165661307